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CANC-011B
[Lys(Me2)370]-p53 (361-380); p53K370Me2
Gly-Ser-Arg-Ala-His-Ser-Ser-His-Leu-Lys(Me2)-Ser-Lys-Lys-Gly-Gln-Ser-Thr-Ser-Arg-His
Size:1mg
P1(RMB):1355
MW:2204.4
One letter sequence:GSRAHSSHL-K(Me2)-SKKGQSTSRH
Molecular Formula:
Description:p53K370Me2 is derived from amino acid residues 361-380 of human p53 tumor suppressor protein, with dimethylation at Lys370. This peptide promotes p53 interactions with both p21gene promoters and p53 binding protein 1 (53BP1), activating transcription of p53 target genes
Literature Reference:Egorova, K. Biochem 75, 535 (2010).
Cas: